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By Isobel W. Jennings

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In the first case, the enzyme is inactivated, in the second it remains active. It is said that lecithinase is inhibited by its antibody. In the case of alkaline phosphatase, it has been shown that the antigenic and the catalytic sites in the enzyme studied were not identical, since inactivation of either site left the remaining site functionally active (Schlamovitz, 1957). There are cases of inherited lack of a specific enzyme in man which can now be treated by injection of the missing substance, but antibodies eventually form against the enzyme, which is usually prepared from animal sources.

Perhaps the most dramatic is the effect of cyanide, which inhibits cytochrome oxidase, with complete cessation of the chain of aerobic oxidation. If the concentration is sufficient—and very little is needed— death results in a few minutes. Both cyanide and carbon monoxide are known as respiratory poisons because of their ability to inhibit cell respiration. It is thought that cyanide combines, in a stable complex, with the heavy metals, copper and iron which are essential for the functioning of the cytochrome oxidase system.

Perhaps the most dramatic is the effect of cyanide, which inhibits cytochrome oxidase, with complete cessation of the chain of aerobic oxidation. If the concentration is sufficient—and very little is needed— death results in a few minutes. Both cyanide and carbon monoxide are known as respiratory poisons because of their ability to inhibit cell respiration. It is thought that cyanide combines, in a stable complex, with the heavy metals, copper and iron which are essential for the functioning of the cytochrome oxidase system.

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