Download Treatment of the Obese Patient (Contemporary Endocrinology) by Robert F. Kushner, Daniel H. Bessesen PDF

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By Robert F. Kushner, Daniel H. Bessesen

The purpose of remedy of the overweight sufferer is to notify clinicians of contemporary advances in weight problems study and supply an up to date overview of present remedy matters and methods. Divided into sections, the 1st part covers new discoveries within the physiological regulate of bodyweight, in addition to the pathophysiology of weight problems. the second one part covers a number of matters which are principal to the scientific administration of overweight sufferer. This quantity is a source that would stimulate and interact clinicians to participate extra effectively within the obesity-care technique.

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179. Kamegai J, et al. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes 2001;50(11):2438–2443. 180. Nakazato M, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409(6817):194–198. 181. Wang L, Saint-Pierre DH, Tache Y. Peripheral ghrelin selectively increases Fos expression in neuropeptide Y-synthesizing neurons in mouse hypothalamic arcuate nucleus. Neurosci Lett 2002;325(1):47–51.

However, the occurrence of low levels of PYY in patients with anorexia nervosa might fall into a different complex psychological entity. PYY3-36 appears to increase in a number of gastrointestinal conditions and following abdominal surgery (40–42). These conditions are usually associated with wasting status and reduced body weight, which further supports PYY’s role as an anorexigenic peptide and a satiety agent. Higher levels of PYY have also been demonstrated in diseases such as malabsorption syndromes including tropical sprue, chronic pancreatitis, and celiac disease (43), following small-intestinal surgery, and with acute gut infection and inflam- Chapter 2 / Gut Peptides 35 matory bowel disease (44).

130. Stephens TW, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995;377:530–534. 131. Schwartz MW, et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 1996; 45:531–535. 132. Bernardis LL, Bellinger LL. The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc Soc Exp Biol Med 1998;218(4):284–306. 133. Kesterson RA, et al. Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome.

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