Download Thyroid Function & Disease by Gerard N. Burrow MD, Jack H. Oppenheimer MD, Robert Volpe MD PDF

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By Gerard N. Burrow MD, Jack H. Oppenheimer MD, Robert Volpe MD

This built-in scientific reference bargains candid assurance and proficient perspectives on thyroid functionality and ailment. rigorously particular line drawings elucidate the discussions by way of three well known clinicians. insurance contains thyroid hormone biosynthesis, laboratory assessment, unhazardous goiter, hyperthyroidism, thyroid affliction in being pregnant, malignant ailments, thyroiditis, and lots more and plenty extra

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Thyroid Function & Disease

This built-in medical reference deals candid assurance and educated perspectives on thyroid functionality and disorder. rigorously distinct line drawings elucidate the discussions through three popular clinicians. insurance comprises thyroid hormone biosynthesis, laboratory assessment, unhazardous goiter, hyperthyroidism, thyroid sickness in being pregnant, malignant ailments, thyroiditis, and masses extra

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J. t \ì AAA... ) Rough [-Translation endoplasmic Assembly kBIycosylation reticulum Smooth endoplasmic [-Glycosylation reticulum ■Glycosylation Golgi packaging Exocytotic ■Secretion vesicles Microvilli l·-Iodination Colloid space Coupling © ® m Φ Thyroglobulin molecules Figure 2-17. Biosynthesis of thyroglobulin. The flow of information is shown from the genomic DNA to the mature iodinated thyroglobulin molecule. The nuclear events include transcription of the thyroglobulin gene that contains putative intervening sequences (thin lines), addition of 7-methylguanosine at the 5' end of the thyroglobulin messenger RNA precursor (abbrevi­ ated as CAP for capping), polyadenylation of the pre­ cursor at its 3' end (abbreviated as AAA.

Himmelhoch, J. , et al. (1971). Effect of lithium on thyroid function. J. Clin. Endocrinol. Metab. 32:647-652;. Burrow, G. N. and Sauer, L. A. (1972). The vectorial release of nascent protein from membrane-bound thy­ roid ribosomes. Endocrinology 91:1307-1313. Burrow, G. , Spaulding, S. , Alexander, N. M. et al. (1973). Normal peroxidase activity in Pendred's syndrome. J. Clin. Endocrinol. Metab. 36:522-530. , and Ferrand, M. (1971). Caracterisation, isolement et propriétés de glycosidases thyroïdiennes : ß-galactosidase, ß-iV-acetylglucosaminidase et α-mannosidase.

Gunma Symposia on Endocrinol­ ogy, Vol. 19. Center for Academic Publications, To­ kyo, Japan. Swillens, S. , et al. (1986). Analysis of sequence and structure homologies between thyroglobulin and acetylcholinesterase: Possible func­ tional and clinical significance. BBRC 137:142-148. , and Lissitzky, S. (1978). Modulation of adenylate cyclase/cyclic AMP response by thyrotropin and prostaglandin E2 in cul­ tured thyroid cells. 1. Negative regulation. Eur. J. Biochem. 90:131-138. , et al. Augmentation of prostacyclin and depression of PGE 2 , PGF 2a and thromboxane A 2 by TSH in cultured porcine thyroid cells.

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