Download Therapy of Moderate-to-Severe-Psoriasis, Second Edition, by Gerald Weinstein, Alice Gottlieb PDF

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By Gerald Weinstein, Alice Gottlieb

This instruction manual positive factors up to date chapters discussing the most recent and most typically prescribed remedies for sufferers with moderate-to-severe psoriasis. issues comprise the administration of paediatric sufferers and sufferers with psoriatic arthritis.

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Extra resources for Therapy of Moderate-to-Severe-Psoriasis, Second Edition,

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Topical agents can be messy and may look or feel unacceptable to the patient. Using quality-of-life parameters, response to treatment has been used to define severity; by this definition severe psoriasis does not have a satisfactory response to treatments that have minimal risks (1). Thus moderate-tosevere psoriasis may, by definition, be moderate to severe because it does not respond to topical agents. Despite their limitations, topical therapies have a useful role in the treatment of moderate-to-severe psoriasis.

A recent review article by Lebwohl notes unpublished data showing that tazarotene has similar potential to reduce corticosteroid-related atrophy (62). Tazarotene also appears to be stable in vitro when combined with a variety of topical corticosteroids and calcipotriene, and does not appear to affect adversely the stability of the other compounds (38). 05% ointment applied twice daily (63). C. Administration Patients using tazarotene as monotherapy should apply the medication once daily, taking care to avoid surrounding unaffected skin.

When used once daily, onset of atrophy is delayed, but does occur, as early as 2–3 months. The scalp is more resistant to atrophy but it does occur; frequently telangiectasia precedes atrophy. Application on one or two consecutive days out of each week, known as pulse therapy, provides adequate maintenance in some patients However, maintenance therapy in combination with calcipotriene or tazarotene is more efficacious (see sections on these agents below). 3. Prescribe the Appropriate Quantity for the Frequency of Application and the Area to be Treated Limiting quantities and refills, requiring frequent follow up and close observation, educating the patient, and combining corticosteroids with other non-steroid therapy will help maximize effectiveness of therapy and minimize side effects.

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