By Andrew M. Tonkin, Eugene Braunwald
The multi-factorial nature of heart problems has very important implications for the making plans of potent remedy techniques. way of life elements equivalent to nutrition, smoking historical past and workout mix with endogenous predictors akin to ethnicity and relations background to provide each person a different danger profile.A complete consultant to dyslipidaemias, this booklet will support cardiologists, and first care physicians of their day-by-day activity of creating a correct overview of the sufferer after which formulating the best administration programme for every manifestation of this complicated crew of disorders.Complex manifestations of lipid issues are reviewed in a scientific context. This booklet is helping early prognosis of disorder and potent remedy concepts to be carried out. It encompasses huge spectrum of pharmacological interventions.
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Additional info for Therapeutic Strategies in Lipid Disorders
Implications for treatment. Circulation 1992; 85:37–45. Rubins HB, Robins SJ, Collins D et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 1999; 341:410–418. Robins SJ, Collins D, Wittes JT et al. Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial.
HDLs AND ENDOTHELIAL REPAIR HDLs enhance endothelial repair by at least two distinct mechanisms. They stimulate endothelial cell migration in a nitric oxide-independent manner via SR-B1-mediated activation of Rac GTPase in a process that depends on the activation of Src kinases, phosphatidylinositol 3-kinase, and p44/42 mitogen-activated protein kinases . In addition, HDLs have the capacity to promote endothelial repair by enhancing the engraftment of endothelial progenitor cells into the endothelium [15, 38].
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