By Philip N. Patsalos, Blaise F. D. Bourgeois
Prescriber's consultant to Antiepileptic medications presents a pragmatic and concise reference advisor to be used by way of all these clinicians and allied health and wellbeing execs that deal with or deal with sufferers with epilepsy. In complete color all through, this quantity offers the antiepileptic medications (AEDs) in alphabetical order and for every AED the knowledge is split into 8 colored sections: normal therapeutics, pharmacokinetics, interplay profile, adversarial results, dosing and use, distinct populations, and steered examining. this convenient pocket advisor could be an exceptional better half for all clinicians that deal with sufferers with epilepsy.
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Extra resources for The Epilepsy Prescriber's Guide to Antiepileptic Drugs
Anti-epileptic drug interactions. A clinical guide. Clarius Press, Guildford, UK; 2005. Riss J, Cloyd J, Gates J, Collins S. Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurologica Scandinavica 2008; 118: 69–86. Sennoune S, Mesdjian E, Bonneton J, Genton P, Dravet C, Roger J. Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. Therapeutic Drug Monitoring 1992; 14: 269–274. Silva RC, Montenegro MA, Guerreiro CA, Guerreiro MM. Clobazam as add-on therapy in children with epileptic encephalopathy.
Mireles R, Leppik IL. Valproate and clonazepam comedication in patients with intractable epilepsy. Epilepsia 1985; 26: 122–126. Patsalos PN. Anti-epileptic drug interactions. A clinical guide. Clarius Press, Guildford, UK; 2005. Sironi VA, Miserocchi G, DeRiu PL. Clonazepam withdrawal syndrome. Acta Neurologica 1984; 6: 134–139. 7 and an empirical formula of C16H13ClN2O.
These doses can be repeated three times over a period of 3 hours. 9% sodium chloride (normal saline) solution (1–2 mg in 250 mL) Dosing tips: • Doses much higher than 2 mg/day are associated with increased risk of dependence • Frequency of dosing in practice is often greater than predicted from half-life, as duration of biological activity is often shorter than the pharmacokinetic terminal half-life • Clonazepam accumulates during prolonged infusion, leading to hypotension, sedation, and finally, respiratory arrest.