By Fred Boogerd (Editor), Frank J. Bruggeman (Editor), Jan-Hendrik S. Hofmeyr (Editor), H.V. Westerhoff
Platforms biology is a full of life and increasing self-discipline, in lots of methods a successor to genomics and maybe unparalleled in its mix of biology with a superb many different sciences, from physics to ecology, from arithmetic to drugs, and from philosophy to chemistry. learning the philosophical foundations of structures biology might get to the bottom of an extended status factor, i.e., the level to which Biology is entitled to its personal clinical foundations instead of being ruled by way of latest philosophies. * solutions the query of what distinguishes the residing from the non-living* An in-depth glance to a energetic and increasing self-discipline, from molecule to method* Explores the sector among person elements and the process
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Additional info for Systems Biology: Philosophical Foundations
Well, the rate and equilibrium equations for most biological processes are nonlinear or at least nonproportional (Hill, 1977; Westerhoff & van Dam, 1987). Moreover, many of the biological processes that are important for function exhibit properties that one would not see in individual molecules and that therefore require nonlinear interactions between those molecules. These processes include differentiation, development, the cell cycle, robust signal transduction and most transport processes. Their theories can only be tested if they are quantitative, and strictly only by quantitative experimentation that is performed inside the living cell.
The former correspond to almost anything that occurs in the environment of living organisms and is useful to them as food. The latter are suitable building blocks for the organism. The pluripotency of metabolism appears limited only by impossibilities stemming from a number of fundamental laws, such as the impossibility to create chemical elements from other chemical elements and the impossibility to generate Gibbs’ free energy (Westerhoff & van Dam, 1987). The consequence is that there are metabolic networks ensuring that sufficient of each of these commodities is harvested from the food and supplied to biosynthesis.
Oxford University Press, Oxford, 2003. Wouters A. The function debate in philosophy. Acta Biotheoretica: 53, 123–151, 2005. This page intentionally left blank SECTION II Research programs of Systems Biology This page intentionally left blank 2 The methodologies of systems biology Hans V. Westerhoff and Douglas B. Kell SUMMARY In this book on philosophical aspects of systems biology, this chapter summarizes the philosophical status of a variety of sciences. Biology, physics and molecular biology offer particular contrast here.