By Vivian Yuan-Hen Ho Hook
215 pages, 34 figures, 20 tables, hardcover this article is designed to supply the reader with an realizing of present wisdom touching on proteases thinking about prohormone processing, and mobile points that has to be thought of for correct processing, garage, and secretion of bioactive peptides. mobile points of the concentrating on and activation of peptide hormones within the secretory pathway are mentioned within the first chapters. the following chapters (chapters 2-6) speak about the endoproteases which are desirous about prohormone processing, together with the subtilisin/kexin of prohormone convertases, a unique cysteine protease referred to as prohormone thiol protease (PTP), and an aspartyl protease that has been termed POMC changing enzyme (PCE). next to the activities of endoproteases, carboxypeptidase and aminopeptidase enzymes (chapter 7) that eliminate uncomplicated amino acids from the COOH- and NH2-termini of peptide intermediates are wanted. furthermore, fresh molecular genetic experiences illustrate the position of prohormone conv! ertases 1 and a pair of, in addition to the carboxypeptidase E/H, processing enzymes in weight problems and prerequisites relating to diabetes. legislation of processing proteases by way of the 7B2 polypeptide as a chaperone and inhibitor is gifted, in addition to a possible function for a relatives of a1-antichymotrypsin protease inhibitors. next to secretion, extracellular proteolysis of neuropeptides and peptide activation of particular receptors is mentioned.
Read Online or Download Proteolytic and Cellular Mechanisms in Prohormone and Proprotein Processing (Molecular Biology Intelligence Unit) PDF
Similar endocrinology & metabolism books
The interdisciplinary paintings revealing diverse roles in organic approaches of persistent illnesses has ended in a brand new box of analysis bearing on universal molecular and scientific positive aspects of power ailments. Epidemiological literature indicates an organization among the heritage of metabolic syndrome/diabetes mellitus style 2 and the chance of constructing a number of cancers.
During this booklet, Harold Morowitz provides a brand new idea at the beginning of existence in the world 4 billion years in the past. Morowitz postulates that step one towards the foundation of existence used to be the spontaneous condensation of amphiphilic molecules to shape vesicles or protocells. This speculation offers a framework for reexamining the emergence of cellularity.
A realistic "how to" advisor for a number of tools in metabolism, with a severe and target dialogue of strengths, obstacles, and applicable functions of the defined tools. Edited by way of the winner of the Oskar-Minkowski Prize of the EASD in 2006 scientific trials in populations prone to or with overt diabetes mellitus are being played everywhere in the international to check novel medicinal drugs and methods to coping with those ailments.
This built-in scientific reference bargains candid assurance and proficient perspectives on thyroid functionality and affliction. rigorously unique line drawings elucidate the discussions by way of three well known clinicians. insurance contains thyroid hormone biosynthesis, laboratory assessment, unhazardous goiter, hyperthyroidism, thyroid sickness in being pregnant, malignant ailments, thyroiditis, and lots more and plenty extra
- Hormone Action Part H: Neuroendocrine Peptides
- Endocrinology: An Integrated Approach
- Radiopharmaceuticals for Therapy
- Mouse Models of Vascular Diseases
- Nuclear Receptors: From Structure to the Clinic
Additional resources for Proteolytic and Cellular Mechanisms in Prohormone and Proprotein Processing (Molecular Biology Intelligence Unit)
Cell 1994; 77(5):625-6. 42. Itin C, Schindler R, Hauri HP. Targeting of protein ERGIC-53 to the ER/ERGIC/cis-Golgi recycling pathway. J Cell Biol 1995; 131(1):57-67. 43. Schimmoller F, Singer-Kruger B, Schroder S et al. The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi. EMBO J 1995; 14(7):1329-39. 44. Itin C, Roche AC, Monsigny M et al. ERGIC-53 is a functional mannose-selective and calcium-dependent human homologue of leguminous lectins.
Powell SK, Orci L, Craik CS et al. Efficient targeting to storage granules of human proinsulins with altered propeptide domain. J Cell Biol 1988; 106:1843-1851. 130. Roy P, Chevrier D, Fournier H et al. Investigation of a possible role of the amino-terminal pro-region of proopiomelanocortin in its processing and targeting to secretory granules. Mol Cell Endocrinol 1991; 82(2-3):237-250. 22 Proteolytic and Cellular Mechanisms in Prohormone and Proprotein Processing 131. Chevrier D, Fournier H, Nault C et al.
J Cell Biol 1995; 131(6 Pt 2):1737-45. 224. Coorssen JR, Schmitt H, Almers W. Ca2+ triggers massive exocytosis in Chinese hamster ovary cells. Embo J 1996; 15(15):3787-91. 225. Rodriguez A, Webster P, Ortego J et al. Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells. J Cell Biol 1997; 137(1):93-104. 226. Herman GA, Bonzelius F, Cieutat AM et al. A distinct class of intracellular storage vesicles, identified by expression of the glucose transporter GLUT4. Proc Natl Acad Sci USA 1994; 91(26):12750-4.