Download OPLL: Ossification of the Posterior Longitudinal Ligament by K. Yonenobu, K. Nakamura, Y. Toyama PDF

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By K. Yonenobu, K. Nakamura, Y. Toyama

This e-book brings jointly details on all facets of OPLL - epidemiology, etiology, prognosis, and therapy. It includes contributions through eastern researchers and surgeons, together with individuals of the Ministry of well-being and Welfare research Committee, and by way of American surgeons with services within the box. previously, little has been released at the topic in English. This number of reviews is abundantly augmented with illustrations.

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Functional Impact of SNPs in COL11A2 In the case of common diseases, even if the genetic susceptibilities are determined by current molecular genetics the daunting task of examining these lifelong genetically determined disturbances by practical experimental procedures remains. Strong evidence of an allelic association with OPLL was observed with the T to A nucleotide substitution at position −4 from the acceptor site in intron 6 [intron 6 (−4A)] in COL11A2, suggesting a functional role of the polymorphism in the pathogenesis of OPLL.

An example of a systemic factor is the metabolic or endocrinological background of an individual, and a common local factor is mechanical stress on the cervical spine. There are racial differences in the incidence of OPLL. OPLL used to be called a Japanese disease because it was rarely found in other countries. Because of this, one of the causes of OPLL is thought to be life style, especially dietary factors. There are reports that patients with OPLL prefer vegetable protein to animal protein, in comparison with controls [12,13], but this hypothesis has not been confirmed by well-designed control studies.

Japanese Ministry of Public Health and Welfare, Tokyo, pp 17–23 12. Terayam K (1987) Family study of ossification of the posterior longitudinal ligament (in Japanese) In: Investigation committee 1986 report on the ossification of the spinal ligament. Japanese Ministry of Public Health and Welfare, Tokyo, pp 10–11 13. Terayam K (1989) Genetic study on ossification of the posterior longitudinal ligament of the spine. Spine 14: 1184–1191 14. Matsunaga S, Sakou T, Taketomi E, Yamaguchi M, Hayasi K, Koga H (1993) Ossification of the spinal ligament and human leukocyte antigen haplotype (in Japanese).

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