Download Nutrition and metabolism by Michael J. Gibney, Ian A. MacDonald, Helen M. Roche PDF

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By Michael J. Gibney, Ian A. MacDonald, Helen M. Roche

During this moment version of moment name within the acclaimed meals Society Textbook sequence, foodstuff and Metabolism has been revised and up to date to satisfy the desires of the modern pupil.

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Ribonucleic acid RNA, like DNA, carries genetic information. The composition of RNA is very similar to DNA, and it plays a key role in all stages of gene expression. RNA is also a linear polynucleotide, but it differs from DNA in that it is single stranded and composed of polymers of ribose rather than deoxyribose, the pyrimidine base uracil (U) replaces thymine (T), and it is relatively unstable when compared to DNA. There are at least five different types of RNA in eukaryotic cells and all are involved in gene expression: ● ● Messenger RNA (mRNA) molecules are long, linear, single-stranded polynucleotides that are direct copies of DNA.

The overall result will be that heterozygosity between animals will reduce and that in the end an inbred strain is obtained with a similar genetic, homozygous background. Genetic homogeneity, however, is not always an advantage. If, for example, the mode of action of a food component is not known or if the main purpose is to test the safety of nutrients or drugs, genetic heterogeneity may be preferable because it increases the extrapolation of results. In addition, differences in responses between various strains can be helpful for elucidating the responses at the molecular level.

Ultimately, this gives information on the rate, proportion and amount of glucose oxidised. Such an approach is instrumental in increasing our understanding of the metabolic consequences of the effects found at the cellular and molecular level. 9/21/2010 9:43:20 PM 26 Nutrition and Metabolism Metabolomics: the most recent tool for nutrigenomics Metabolomics represents the newest ‘omics’ technology being applied within molecular nutrition and nutrigenomics. It utilises analytical chemistry technologies such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) to capture complete data on the low molecular weight metabolites, nutrients and other compounds in various human biofluids, cells and tissues.

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