Download Neuroendocrine Control of the Thymus (Neuroimmunomodulation, by W. Savino PDF

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By W. Savino

Analyzing neuroendocrine keep an eye on of the thymus, this quantity investigates using neuroendocrine hormones to advertise reconstitution after bone marrow transplantation; thymic expression of the the pancreatic endocrine hormones; and the position of growing older within the immune-endocrine loop and thymus-pituitary axis. Thymic tissues, thymic stroma and thymulin cells function prominently in admire of animal trying out, and regeneration of the thymus.

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J Neurosci 1993;13:2136– 2148. 23 Donnerer J, Schuligoi R, Stein C: Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo. Neuroscience 1992;49:693–698. 24 Woolf CJ, Safieh-Garabedian B, Ma Q-P, Crilly P, Winter J: Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 1994;62:327– 331. 44 25 Safieh-Garabedian B, Kanaan SA, Haddad JJ, Abou Jaoude P, Jabbur SJ, Saadé NE: Involvement of interleukin-1ß, nerve growth factor and prostaglandin-E2 in endotoxin-induced localized inflammatory hyperalgesia.

Cell Immunol 1982;70:362–366. 32 Rinaldi-Garaci C, Jezzi T, Baldassare AM, Dardenne M, Bach JF, Garaci E: Effect of thymulin on intracellular cyclic nucleotides and prostaglandin E2. Eur J Immunol 1985;15: 548–552. 33 Aono H, Morishita M, Sasano M, Okamoto M, Okahara A, Nakata K, Mita S: Amelioration of type II collagen-induced arthritis in rats by treatment with thymulin. J Rheumatol 1997; 24:1564–1569. 34 Safieh-Garabedian B, Major SC, Jabbur SJ, Atweh SF, Saadé NE: Thymulin-induced hyperalgesia is mediated through capsaicin-sensitive primary afferent fibers.

Most depolarizations were of a smaller magnitude although other depolarizations to positive membrane voltages were seen. B Application of progesterone induced an inward current. Here, repeated applications of 1 mM progesterone are shown illustrating both the inward current and the desensitization seen. C Depolarization of the cell in response to progesterone was dose-dependent. 0 and 10 mM is shown. ** p ! 01. 34 Neuroimmunomodulation 1999;6:31–38 (y-axis) with time (x-axis) in the cell shown as an inset.

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