By G. Brown
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Extra resources for Molecular Cloning - Selected Applns. in Medicine and Biology
2000). Several advantages of dendrosomes confer them other potentials for use in DNA vaccination. These include protection of plasmid DNA from nuclease degradation, efficient delivery of their contents to antigen presenting cells (APCs) and extended release of cargo. , 2000). , 2006). , 2001). , 2006). , 2007). Another group has recently synthesized and used dendrosomes containing entrapped PPI dendrimer-DNA complexes in genetic immunization against hepatitis B as well. The dendrosome formulation chosen for this study was DF3 as it possessed optimum size and entrapment efficiency.
Massumi M, et al (2005). Apoptosis induction in human lymphoma and leukemia cell lines by transfection via dendrosomes carrying wild type p53 cDNA. Biotechnol Lett. 28: 61-66. Moghimi SM, Szebeni (2003). Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog Lipid Res. 42:463-478. Nishikawa M, Takemura S, Takakura Y, Hashida M (1998) . Targeted delivery of plasmid DNA to hepatocytes in vivo: optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(l-lysine) complexes by controlling their physicochemical properties.
In: Methods in molecular biology, Vol7: Gene transfer and expression protocols edited by Murray EJ Clifton, Humana Press Inc, pp: 169-173. Hashida M, Takemura S, Nishikawa M, Takakura Y (1998). Targeted delivery of plasmid DNA complexed with galactosylated poly(l-lysine). J Control Release 53:301– 310. Holter W, Fordis CM , et al (1989). Efficient gene transfer by sequential treatment of mammalian cell with DEAE-Dextran and deoxyribonucleic acid. Exp Cell Res. 184:546-551. Kawasaki ES, Player A (2005).