Download Mechanisms of insulin action by Alan R. Saltiel, Jeffrey E. Pessin PDF

By Alan R. Saltiel, Jeffrey E. Pessin

More than 18 million humans within the usa have diabetes mellitus, and approximately ninety% of those have the kind 2 type of the illness. additionally, among 17 and forty million humans have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities mentioned variably because the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of those problems, a important element of the pathophysiology is insulin resistance, i.e., decreased responsiveness to insulin in tissues corresponding to muscle, fats and liver. Insulin resistance is additionally heavily associated with different universal illnesses, together with weight problems, polycystic ovarian affliction, hyperlipidemia, high blood pressure, and atherosclerosis. during this ebook, we'll try and dissect the complexity of the molecular mechanisms of insulin motion with a different emphasis on these gains of the process which are topic to alteration in sort 2 diabetes and different insulin resistant states. We discover insulin motion on the most simple degrees, via advanced structures. The booklet should be attractive to easy and medical scientists.

Show description

Read Online or Download Mechanisms of insulin action PDF

Similar endocrinology & metabolism books

Diabetes and Cancer: Epidemiological Evidence and Molecular Links

The interdisciplinary paintings revealing assorted roles in organic strategies of power ailments has ended in a brand new box of analysis bearing on universal molecular and medical positive factors of continual illnesses. Epidemiological literature indicates an organization among the heritage of metabolic syndrome/diabetes mellitus sort 2 and the danger of constructing various cancers.

Beginnings of Cellular Life: Metabolism Recapitulates Biogenesis

During this ebook, Harold Morowitz offers a brand new conception at the beginning of lifestyles in the world 4 billion years in the past. Morowitz postulates that step one towards the foundation of existence used to be the spontaneous condensation of amphiphilic molecules to shape vesicles or protocells. This speculation offers a framework for reexamining the emergence of cellularity.

Clinical Diabetes Research: Methods and Techniques

A realistic "how to" advisor for a number of equipment in metabolism, with a severe and target dialogue of strengths, boundaries, and acceptable functions of the defined equipment. Edited through the winner of the Oskar-Minkowski Prize of the EASD in 2006 medical trials in populations vulnerable to or with overt diabetes mellitus are being played all over the global to check novel medicinal drugs and ways to handling those ailments.

Thyroid Function & Disease

This built-in scientific reference bargains candid assurance and expert perspectives on thyroid functionality and affliction. conscientiously specific line drawings elucidate the discussions via three popular clinicians. insurance comprises thyroid hormone biosynthesis, laboratory evaluate, unhazardous goiter, hyperthyroidism, thyroid affliction in being pregnant, malignant ailments, thyroiditis, and masses extra

Extra info for Mechanisms of insulin action

Example text

Brandt J, Andersen AS, Kristensen C. Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affmity. J Biol Chem 2001; 276:12378-12384. 175. Surinya KH, Molina L, Soos MA et al. Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies. J Biol Chem 2002; 277:16718-16725. 176. Kristensen C, Andersen AS, Ostergaard S et al. Functional reconstitution of insuUn receptor binding site from nonbinding receptor fragments.

184. Ottensmeyer FP, Beniac DR, Luo RZ et al. Mechanism of transmembrane signaling: Insulin binding and the insulin receptor. Biochemistry 2000; 39:12103-12112. 185. Yip CC, Ottensmeyer P. Three-dimensional structural interactions of insulin and its receptor. J Biol Chem 2003; 278:27329-27332. 186. Blundell TL, Dodson GG, Hodgkin DC et al. Insulin: The structure in the crystal and its reflection in chemistry and biology. Adv Prot Chem 1972; 26:279-402. Insulin and IGF-I Receptor Structu re and Binding Mechan ism 31 187.

Biochem Biophys Res Comm 1993; 192:905-911. 143. Nakae J, Morioka H, Ohtsuka E et al. Replacements of leucine 87 in human insuHn receptor alter affinity for insulin. J Biol Chem 1995; 270:22017-22022. 144. Liu R, Zhu J, Jospe N et al. Deletion of lysine 121 creates a temperaturesensitive alteration in insuhn binding by the insulin receptor. J Biol Chem 1995; 270:476-482. 145. Rique S, Nogues C, Ibanez L et al. Identification of three novel mutations in the insulin recepor gene in type A insulin resistant patients.

Download PDF sample

Rated 4.85 of 5 – based on 4 votes