By Jan de Boer, Clemens A. van Blitterswijk
This entire, but concise, consultant introduces you to the speedily constructing box of excessive throughput screening of biomaterials: materiomics. Bringing jointly the foremost recommendations and methodologies used to figure out biomaterial houses, you are going to comprehend the difference and alertness of materomics in components equivalent to fast prototyping, lithography and combinatorial chemistry. every one bankruptcy is written by way of the world over well known specialists, and contains educational paragraphs on themes equivalent to biomaterial-banking, imaging, assay improvement, translational points, and informatics. Case experiences of state of the art experiments supply illustrative examples, while lists of key guides let you simply learn up at the such a lot appropriate heritage fabric. even if you're a specialist scientist in undefined, a pupil, or a researcher, this booklet isn't to be overlooked while you are drawn to the newest advancements in biomaterials study.
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Extra info for Materiomics: High-Throughput Screening of Biomaterial Properties
14. Tweedie CA, Anderson DG, Langer R, Van Vliet KJ. Combinatorial material mechanics: High-throughput polymer synthesis and nanomechanical screening. Adv Mater. 2005;17 (21):2599–+. 15. Sundararajan G, Roy M. Hardness testing. , eds. Encyclopedia of Materials: Science and Technology: Elsevier; 2001. p. 3728–36. 16. Oliver WC, Pharr GM. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments. J Mater Res. 1992;7(6):1564–83. 28 E.
W. Grijpma materials, and relate primarily to the variable properties on the chemical level (molecular structure, functional groups and degradation). Therefore, the chemistry of a biomaterial directly contributes to its interaction with biological environments. Combinatorial chemistry and high-throughput analysis is being developed to correlate these material properties to the biological outcome and eventually ﬁnd the ultimate biomaterial. 1 Bulk characteristics Chemical properties The properties of polymeric biomaterials on the chemical level deal with the information on the structural units, namely what type of monomer comprises the polymer chain and whether one or more than one type of monomer (copolymer) is used.
Kim B-S, Park I-K, Hoshiba T et al. Design of artiﬁcial extracellular matrices for tissue engineering. Prog Polym Sci. 2011;36(2):238–68. 7. Pego AP, Grijpma DW, Feijen J. Enhanced mechanical properties of 1,3-trimethylene carbonate polymers and networks. Polymer. 2003;44(21):6495–504. 8. Pego AP, Poot AA, Grijpma DW, Feijen J. Copolymers of trimethylene carbonate and epsilon-caprolactone for porous nerve guides: Synthesis and properties. J Biomat Sci Polym E. 2001;12(1):35–53. 9. Washburn NR, Yamada KM, Simon Jr CG, Kennedy SB, Amis EJ.