By N. Sitaras
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Extra resources for Evidence-Based Medicine - Closer to Patients or Scientists
9, (July 1997), pp. 1-65, 1366-5278 Bandolier. ). Surrogate Endpoints. html Benitez-Bribiesca, L. (1999). Evidence-based medicine: A new paradigm? Archives of Medical Research, 30, 2, (March-April 1999), pp. 77-79, 0188-4409 Bodenheimer, T. (1999). The movement for improved quality of health care. New England Journal of Medicine 340, 6, (February 1999), pp. 488-492, 0028-4793 Borgmeyer, C. (2005). Guideline showcases AAFP’s commitment to evidence-based, patientcentered care. Annals of Family Medicine, Vol.
It is more likely, however, that “the intervention affects the clinical outcome by unintended, unanticipated, and unrecognized mechanisms of action that operate independently of the disease process” (Fleming & DeMets, 1996). Fleming and DeMets argue that surrogate endpoints frequently mislead regarding the actual effects that treatments have on health outcomes. For instance, although lipid levels are widely seen to be important predictors of cardiovascular-related mortality, there is debate over the relationship between lipid lowering and reduction in overall mortality.
Cfm&CAT=none Cournoyer, B. R. (2004). The Evidence-Based Social Work Skills Book, Pearson, 0205358624, Boston Culpepper, L. & Gilbert, T. T. (1999). Evidence and ethics. Lancet, Vol. 353, No. 9155, (March 1999), pp. , & Frankel, S. (2001). How policy informs the evidence. British Medical Journal, Vol. 322, No. 7286, (January 2001), pp. 184-185, 0959-8138 Dawson, N. V. & Arkes, H. R. (1987). Systematic errors in medical decision making: Judgment limitations. Journal of General Internal Medicine, Vol.