By Jong Rho, Raman Sankar, Carl E. Stafstrom
Epilepsy has bothered humankind all through recorded heritage; but, it's only within the final half-century, that major development has been made in our uncomplicated realizing of the epileptic mind. Pivotal advances in drug improvement and surgical ideas, in addition to the emergence of cutting edge techniques similar to electric stimulation of the worried approach, have ended in a considerable relief within the morbidity and mortality of sufferers with epilepsy. while, outstanding advancements in neuroscience have superior our realizing of mind constitution and function.
Epilepsy: Mechanisms, versions, and Translational views contains new translational advances that carry epilepsy remedies from the laboratory bench to the bedside and again back. It brings jointly the paintings of greater than 70 of the field’s most dear and state of the art researchers and clinicians. In 24 chapters, this terribly entire and present work:
Offers an outline of the fundamental anatomic and sensible substrates of seizure genesis and considers novel pathogenic techniques that experience either emerged and been verified experimentally
— Examines antiepileptic drug treatment, together with the most recent on molecular targets
— appears to be like on the kingdom of surgical remedies for epilepsy and discusses advances within the fields of structural and sensible neuroimaging
— studies the range of nontraditional healing techniques, corresponding to the ketogenic vitamin, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals
— Investigates neuroendocrine, hormonal, and biobehavioral elements that impression seizure susceptibility—information that may be integrated into the layout of remedy algorithms on an individualized basis
— offers a glimpse of what destiny epilepsy treatments could seem like, from novel mechanisms of drug supply to gene and stem-cell remedies for epilepsy to seizure detection equipment, to the last word target of affliction prevention.
The proposal for this publication used to be encouraged through the editors’ collective wish to advertise bridging of the so-called translational divide—that is, masking leading edge therapy thoughts in line with medical rules that experience but to be validated carefully within the medical environment, yet but may supply practitioners with new and promising ways towards epilepsy therapeutics.
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Extra resources for Epilepsy: Mechanisms, Models, and Translational Perspectives
E. Stafstrom. (2006). Neurophysiology of epilepsy. In Pediatric Neurology: Principles and Practice, 4th ed. (pp. F. Swaiman, S. M. Ferriero, Eds. Philadelphia, PA: Mosby. , J. A. Payne, E. Ruusuvuori, H. Lahtinen, K. Lamsa, U. Pirvola, M. Saarma, K. Kaila. (1999). The K+/Cl– co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature, 397:251–255. A. Siegelbaum. (2003). Hyperpolarization-activated cation currents: from molecules to physiological function. Annu. Rev. , 65:453–480.
In addition, excitability in the developing brain varies by brain region and cell type. Much of this information is derived from experimental epilepsy models in rodents, in which a window of heightened excitability in the second postnatal week gives rise to a lowered seizure threshold. , 2002). For many reasons, the excitatory/inhibitory balance in the brain changes dramatically over the course of early development. The disadvantage of these physiological adaptations is that the brain is especially vulnerable to hyperexcitability and seizure generation during a critical window of development.
M. Rho. (2004). Molecular biology and ontogeny of glutamate receptors in the mammalian central nervous system. J. , 19:343–361. S. (2008). Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the “latent period” and other concepts. Epilepsia, 49(Suppl. 9):85–92. , 3rd. (1995). Basic mechanisms of generalized absence seizures. Ann. , 37:146–157. E. (2004). An introduction to seizures and epilepsy: cellular mechanisms underlying classification and treatment.