Download Epilepsy in Women: The Scientific Basis for Clinical by Barry Gidal, Cynthia L. Harden PDF

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By Barry Gidal, Cynthia L. Harden

This quantity publications the practitioner within the present administration of girls with epilepsy, in a accomplished and scientifically proficient demeanour. Many chapters are dedicated to a few of the facets of being pregnant administration for girls with epilepsy, from decreasing the dangers of medicine publicity to breast feeding. All girl age teams are mentioned and chapters on matters vital for youth and the mature girls also are integrated. The editors have integrated the world over well-known specialists as members, to compile a physique of information exceptional in earlier settings. This ebook may be a consultant to administration for ladies with epilepsy for years yet to come, because of its strong medical foundation and the excellent imaginative and prescient of the individuals. * good points discussions on matters for ladies with epilepsy that span "from the lab to the clinic"* Encompasses the present country of this evolving subject * prepared in discreet scientific entities for simple reference with important tables and figures

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Additional resources for Epilepsy in Women: The Scientific Basis for Clinical Management

Sample text

One model that has been used to investigate the neurobiological substrates associated with sex diVerences in seizure susceptibility is infusions of muscimol, a -aminobutyric acid (GABAA) receptor agonist, to the substantia nigra pars reticulata (SNR). , 2003). Infusions of muscimol to the SNR at postnatal day 15 (PND15), produce seizures among male, but not female, rats (Velı´sˇkova´ and Moshe´, 2001). , 2003). These findings suggest that sex diVerences in seizure susceptibility occur early in development and may be somewhat independent of the activational eVects of steroids that begin to be secreted at puberty.

This has implications both for prognosis and for our understanding of seizure pathophysiology. Before going into details of these interesting diVerences, it is important to briefly review the classification of epilepsy, and to explain some methodological principles that are important in interpreting epidemiologic studies of epilepsy. II. Classification of Epilepsy and Seizures Classification of seizures and epilepsy syndromes is an important part of clinical work. Appropriate classification relies on detailed history and a collateral account, neurologic examination, and the interpretation of specialized tests— notably electroencephalography (EEG) and neuroimaging.

18 MCHUGH AND DELANTY consistent with the greater risks for lesional epilepsy in elderly males. Within this, generalized epilepsies are more common in females in the first year of life, after which incidences for both genders converge and remain similar until 45 years, when a slight male excess becomes apparent (Fig. 4). Generalized epilepsy syndromes characterized by absence seizures were diagnosed typically in childhood and early adulthood, as was the greatest incidence of generalized myoclonic epilepsies.

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