Download Contemporary Aspects of Biomedical Research: Drug Discovery by S.J. Enna and Michael Williams (Eds.) PDF

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By S.J. Enna and Michael Williams (Eds.)

Every one quantity of Advances in Pharmacology offers a wealthy choice of reports on well timed subject matters. Emphasis is put on the molecular foundation of drug motion, either utilized and experimental.Articles written by way of major investigators within the fieldInforms and updates on the entire newest advancements

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13-SHydroxyoctadecadienoic acid, 13-S-HODE; hydroxyeicosatetraenoic acid, HETE. T-shaped arrows: inhibition. , 2003). The results showed additive effects of the two antagonists indicating independent mechanisms of action. Thus, combination treatment has potential for the chemoprevention of colon carcinogenesis. , 2001). , 2004). , 2004). , 1994). Aromatase-dependent estrogen biosynthesis has been linked to hormone-dependent breast carcinogenesis, and PGE2 is a potent inducer of CYP19 transcription via a cAMP-dependent mechanism in vitro (Cai, Kwintkiewicz, Young, & Stocco, 2007).

Woolf, C. J. (2009). Neuropathic pain: A maladaptive response of nervous system to damage. Annual Review of Neuroscience, 32, 1–32. , & Thiam, K. (2008). Use of genetically modified rat models for translational medicine. Drug Discovery Today, 13, 488–494. Cuatrecasas, P. (2006). Drug discovery in jeopardy. Journal of Clinical Investigation, 116, 2837–2842. , De Lange, E. C. , Pasqua, O. , Ploeger, B. , & Voskuyl, R. A. (2007). Mechanism-based pharmacokinetic/pharmacodynamic modeling: Biophase distribution, receptor theory, and dynamical systems analysis.

Robert, J. S. (2008). The ethos and ethics of translational research. American Journal of Bioethics, 8, 43–51. Mankoff, S. , & Marincola, F. M. (2004). Lost in translation: Obstacles to translational medicine. Journal of Translational Medicine, 2, 14. Marino, M. , Knutsen, L. S. , & Williams, M. (2008). Emerging opportunities for antipsychotic drug discovery in the postgenomic era. Joruanl of Medicinal Chemistry, 51, 1077–1107. Marks, A. R. (2006). Rescuing the NIH before it is too late. Journal of Clinical Investigation, 116, 844.

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