By Robert Petro, Mordechay Schlesinger (auth.), Mordechay Schlesinger (eds.)
Medical purposes of Electrochemistry, a quantity of the sequence sleek elements of Electrochemistry, illustrates the interdisciplinary nature of contemporary technological know-how via indicating the numerous present concerns in drugs which are at risk of answer through electrochemical tools. This publication additionally indicates how customized drugs can develop.
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2011;22:899–906. 64. Hench LL. Biomaterials: a forecast for the future. Biomaterials. 1998; 19:1419–23. 65. Kundu B, Soundrapandian C, Nandi SK, Mukherjee P, Dandapat N, Roy S, Datta BK, Mandal TK, Basu D, Bhattacharya RN. Development of new localized drug delivery system based on ceftriaxone-sulbactam composite drug impregnated porous hydroxyapatite: a systematic approach for in vitro and in vivo animal trial. Pharm Res. 2010;27:1659–76. 66. Gravens DL, Margraf HW, Butcher HR, Ballinge WF. The antibacterial effect of treating sutures with silver.
Schlesinger hydroxyapatite coatings . The use of Ag has also been explored as surface coatings on external bone fixing elements, elements that form an interface between the surface of the skin, which is normally colonized by bacteria, and the bone tissue, the infection of which provides the most significant complication . Coatings of Ag on 316L SS by means of vapor-phase ionbeam-assisted deposition for infection prevention of external bone fixation devices have shown positive results in the prevention of bacteria proliferation, while raising concerns over a potentially high release of Ag+ ions from surface coatings, confirmed by its increase in blood concentration in vivo [69, 70].
Home monitoring for coagulation status (measurement of clot formation time) is available in several devices utilizing different analysis methods, two of which are based on electrochemical principles. The CoaguCheck of Roche Diagnostics involves paramagnetic iron oxide particles which are mixed with thromboplastin reagent (that initiates the clotting cascade in reaction to a drop of blood) and the movement of the particles in response to an electromagnet which is restricted as a clot forms. Another device, the INRatio Prothrombin Time Monitoring System, detects an impedance difference between electrodes during clot formation .