By C. Weissmann (auth.), Manuel J. T. Carrondo, Bryan Griffiths, José L. P. Moreira (eds.)
Animal mobile know-how has gone through a swift transformation over the past decade from a learn instrument and hugely specialized know-how to a critical source for innovation in pharmaceutical study and improvement. those court cases of the 14th assembly of the ecu Society for Animal mobilephone expertise (Vilamoura, Portugal, may possibly 1996) increase up to now the ancient viewpoint of animal telephone know-how for the good thing about society, `From Vaccines to Genetic Medicine', and may constitution this very important expertise for the future years.
robust contributions are grouped within the conventional ESACT parts of 'Cell and body structure Engineering' facing phone kingdom, together with genetics, and its atmosphere, and 'Animal telephone method Engineering' masking integration of bioreaction with bioseparation coupled with online tracking to enhance protein construction and consistency. vast assurance of metabolic engineering on synthesis, folding, meeting, transiting and secretion is handled within the consultation on 'Recombinant Proteins: Biosynthesis and Bioprocessing'. conventional yet increasing parts of animal phone know-how relevance are highlighted within the extensive periods of 'Animal Cells as instruments for Discovery and checking out' and 'Animal telephone Vaccines: current and Future'. classes eventually disguise the newer domain names of animal mobile expertise paintings - 'Tissue Engineering and Biomedical units' and 'Cells and Vectors for Genetic medication' - the place you can actually foresee a really vibrant future.
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Additional info for Animal Cell Technology: From Vaccines to Genetic Medicine
Virol. 53, 100-106. 4. Hansen M, Jelinek L, Whiting S, and Barklis E (1990) Transport and assembly of gag proteins into Moloney murine leukemia virus. J. Virol. 64, 5306-5316. 5. Deo Y, Ghebremariam, Hand Cloyd, M (1994) Detection and characterization of murine ecotropic recombinant virus in myeloma and hybridoma cells . Hybridoma 13, 69-76. TOWARD A DNA VACCINE AGAINST LYSSAVIRUSES. C. Bahloul, F. Fouque, N. Tordo, Y. Jacob and P. Perrin. Laboratoire des Lyssavirus lnstitut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France Abstract Classical rabies vaccine strains (genotype 1) protect inefficiently against rabies-related lyssaviruses (other genotypes) and in particular against the Mokola virus (genotype 3).
G. and Sandoz Pharma AG 1 , Basle, Switzerland SUMMARY We have established a 'nested PCR' technique for the group-specific detection of murine Ctype retroviruses to screen cell lines for the presence of contaminants. Analyses confirmed that a well known myeloma cell line, Sp2/0, is contaminated with a retrovirus. The genome of the retrovirus was isolated and characterized by nucleic acid sequencing. The genomic organization of this retrovirus is typical for a murine C-type retrovirus. However, numerous differences could be found in the primary structure of gag and the integrase protein.
The results are mixed. In some cases it will enhance protein secretion, presumably by preventing mis-folding. In other cases it inhibits secretion by causing enhanced retention. My instincts are rather than to engineer standard cells to have a look at myeloma cells, hepatoma cells, or some of the others - particularly if you are having trouble making a protein with a lot of disulphide bonds. My instincts are to go back to nature and try and get the cells to do the work for you rather than to try and take a fibroblast which, of course, specialises in making collagen and try to re-engineer all the proteins most of which we do not know, to get the cell to make say a disulphide bonded protein.