Download Anesthesia & Analgesia Vol 109 Issue 01 2009 by International Anesthesia Research Society PDF

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Rocuronium was administered to facilitate tracheal intubation and muscle relaxation. 25% with epinephrine (1 mL/kg up to 15 mL), clonidine (2 ␮g/kg), and preservative-free morphine (40 ␮g/kg). Intraoperative opioids were minimized in an effort to tracheally extubate all patients before leaving the operating room. In extubated patients, dexmedetomidine, and fentanyl were titrated to patient comfort. In neonates and in patients who would remain intubated, anesthesia was further supplemented with 10 –30 ␮g/kg fentanyl.

13 aprotinin’s use was associated with a twofold increase in the risk of renal failure and the need for dialysis. 14 described a dose-related effect of aprotinin on postoperative creatinine levels but did not note a significant increased risk of dialysisdependent renal failure. 11 in a randomized controlled trial study also concluded that the use of aprotinin did not increase the need for postoperative renal dialysis. However, there was an increase in the proportion of patients exposed to aprotinin that had a doubling of postoperative serum creatinine levels.

6 mg/dL and platelet count of 139,000/␮L. The blood loss was approximately 400 mL/h; however, after the transfusion of a 300 mL IAT blood, there was a marked increase in the blood loss to approximately 600 mL/h reaching a maximum of 1600 mL/h at the end of the procedure. IAT blood continued to be transfused during surgery. 5 h hemaglobinuria was documented and apparent on visual inspection (Fig. 1, noon). There was a progressive darkening of the urine (Fig. 1, 1400) and increasing coagulopathy.

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