By David A. Bender
Amino Acid Metabolism, 3rd Edition covers all facets of the biochemistry and dietary biochemistry of the amino acids. beginning with an summary of nitrogen fixation and the incorporation of inorganic nitrogen into amino acids, the publication then information different significant nitrogenous compounds in micro-organisms, crops and animals. Contents comprise a dialogue of the catabolism of amino acids and different nitrogenous compounds in animals, and the microbiological reactions excited about unencumber of nitrogen gasoline again into the ambience. Mammalian (mainly human) protein and amino acid requisites are thought of intimately, and the equipment which are used to figure out them.
Chapters ponder person amino acids, grouped in keeping with their metabolic starting place, and discussing their biosynthesis (in vegetation and micro-organisms for people that are nutritional necessities for human beings), significant metabolic roles (mainly in human metabolism) and catabolism (again usually in human metabolism). there's additionally dialogue of regulatory mechanisms for a lot of these metabolic pathways, and of metabolic and genetic illnesses affecting the (human) metabolism of amino acids.
Throughout the ebook the emphasis is at the dietary value of amino acids, integration and regulate of metabolism and metabolic and different disturbances of relevance to human biochemistry and health.
- Completely revised variation of this entire textual content masking the entire most recent findings in amino acid metabolism research
- Written by way of an expert within the box
- Covers new advances in structural biology
- Clear illustrations of all buildings and metabolic pathways
- Full checklist of urged additional interpreting for every bankruptcy and bibliography of papers stated within the text
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Additional resources for Amino Acid Metabolism
2007). By contrast, there are a number of dominant genetic conditions in which the activity of PRPP synthetase is elevated. In most cases, the problem is over-expression of the gene for PRPP synthetase I, with no effect on the kinetics of the reaction. In other cases, this is the result of either an increase in the Vmax of the enzyme, with no difference in the values of Km for the substrates, or sensitivity to inhibitors, or reduced sensitivity of the enzyme to feedback inhibition by ADP and GDP, which can be considered to be end products of PRPP metabolism.
4), and impaired activity of any of them will lead to an increase in the intracellular concentration of PRPP and, hence, increased de novo purine synthesis. 4 Mammalian enzymes that utilize phosphoribosyl pyrophosphate. 2 PRPP amidotransferase The synthesis of phosphoribosylamine from PRPP is the ﬁrst committed step of purine synthesis, and the main regulatory step. It is also the ﬁrst step for synthesis of the pyrimidine ring of thiamin (vitamin B1). , 2007). The activity of human PRPP amidotransferase is exquisitely sensitive to the intracellular concentration of PRPP, having an apparent Km of 140 μmol/l, compared with a normal intracellular concentration of 2–30 μmol/l.
1). As well as being a substrate, aspartate also activates the enzyme by binding to a separate regulator site together with a divalent metal ion. The reverse reaction provides an industrially important source of aspartate for synthesis of the sweetener aspartame (β-methylaspartyl phenylalanine). , 2008). There are two isoenzymes of glutamate dehydrogenase in plants, an NADH-dependent enzyme in mitochondria and an NADPH-dependent enzyme in chloroplasts. Both enzymes have a relatively high Km for ammonium, and thus function mainly to release ammonium from glutamate for incorporation into glutamine.