By National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
Super dangerous ingredients (EHSs)² should be published unintentionally due to chemical spills, business explosions, fires, or injuries concerning railroad autos and vehicles transporting EHSs. employees and citizens in groups surrounding business amenities the place EHSs are synthetic, used, or kept and in groups alongside the nation's railways and highways are possibly prone to being uncovered to airborne EHSs in the course of unintentional releases or intentional releases via terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental security employer (EPA) has pointed out nearly four hundred EHSs at the foundation of acute lethality info in rodents. As a part of its efforts to improve acute publicity instruction degrees for EHSs, EPA and the company for poisonous ingredients and ailment Registry (ATSDR) in 1991 asked that the nationwide learn Council (NRC) increase instructions for setting up such degrees. in keeping with that request, the NRC released instructions for constructing neighborhood Emergency publicity degrees for dangerous elements in 1993. as a result, regular working tactics for constructing Acute publicity instruction degrees for dangerous components was once released in 2001, offering up-to-date methods, methodologies, and different instructions utilized by the nationwide Advisory Committee (NAC) on Acute publicity guide degrees for harmful components and the Committee on Acute publicity instruction degrees (AEGLs) in constructing the AEGL values. In 1998, EPA and DOD asked that the NRC independently assessment the AEGLs built by means of NAC. in accordance with that request, the NRC geared up inside of its Committee on Toxicology (COT) the Committee on Acute publicity instruction degrees, which ready this document. Acute publicity instruction degrees for chosen Airborne chemical substances is the 10th quantity of the sequence and files for N,N-dimethylformamide, jet propellant fuels five and eight, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.
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Extra info for Acute Exposure Guideline Levels for Selected Airborne Chemicals
1983; Lundberg et al. 1986; Roure et al. 1996). The cause of death following acute inhalation exposure was not identified. Repeated inhalation exposure of rats, mice, and cats to DMF generally resulted in reduced body weight, and hepatotoxicity indicated by increased liver enzymes and histopathologic changes including degeneration and necrosis. However, repeated inhalation exposure of monkeys to DMF at 500 ppm for 6 h/day, 5 days per week, for up to 13 weeks failed to result in any measurable adverse effects (Hurtt et al.
Rats exposed to DMF at 314 ppm developed increased AST (+38%) compared with controls. Sherman rats exposed to a saturated vapor concentration of DMF for 4 h survived (no further experimental details provided (Smyth and Carpenter 1948). The concentration used was interpreted as 3,500 ppm (at 20°C) by the National Institute for Occupational Safety and Health (NIOSH 1996) in the original immediately dangerous to life or health (IDLH) derivation as described by Clayton et al. (1963). 01. Abbreviations: SDH, serum sorbitol dehydrogenase; GDH, glutamate dehydrogenase.
05) in rats exposed at 280 or 560 ppm (1/16 or 1/8 of the saturation concentration; exact SDH values not provided) compared with controls, the greatest increase occurring in rats exposed at 560 ppm. SDH concentrations were comparable to control levels in all other exposure groups, including those that inhaled 1,120 or 2,250 ppm. No abnormalities were observed during histologic examination of livers from rats exposed at 2,250 ppm DMF for 4 h. Groups of 10 male Sprague-Dawley rats inhaled DMF at measured concentrations of 0, 81, 153, 313, 441, or 991 ppm for 4 h in a 200-L dynamic inhalation chamber (with adjustable laminar airflow ranging from 10 to 20 m3/h) at 23°C (Roure et al.